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Would you apply the strategy/science/culture framework differently at the 0-to-1 stage, vs at a later, more established stage? Anything come to mind immediately?

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At early 0 to 1 strategy is largely about finding something that delights w/ less focus on hard to copy and margin. Consumer science relies much more on intuition and I don’t think convos about culture need to start until 15-20 peeps are in the building.

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To carry question 3 a bit further: given that a product strategy is wrong +/- 50% of the time, how can you ensure you're at a company where that sort of failure is permissible, expected, and, ideally, welcomed in these high-stakes decisions?

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That brings things back to the culture that helps define the skills and behaviors that give shape to the environment for risk-taking, intellectual curiosity, courage, candor, etc. Start with strategy (a plan), use consumer science to determine what works/doesn't, and, over time, the culture becomes the storehouse for knowledge/judgement in making great decisions about people, product and the business. Over time, you do become better guessers.

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